KicStart
Type 2 Diabetes
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What is Type 2 Diabetes?

Insulin acts like a courier to move glucose (sugar) out of the blood and into cells. Type 2 diabetes occurs when insufficient insulin is produced to meet the body’s needs or the insulin that is produced doesn’t work properly. As a result, cells and muscles don’t receive enough glucose (the main source of energy) to function properly while at the same time the sugar accumulates in the bloodstream (high blood sugar).

This accumulation of glucose in the blood stream is in turn associated with increased oxidative stress. This is important because oxidative stress is believed to play a central role in the development of atherosclerosis and contribute to obesity related diseases such as hypertension as well as diabetes itself *.

What increases the risk of developing type 2 diabetes?

The risk of developing type 2 diabetes is increased in those people who:

  • are overweight
  • are physically inactive
  • have poor nutrition
  • smoke
  • have a family history of diabetes
  • have a genetic or ethnic pre-disposition

 
What's KicStart
 
 
 

Although risk factors like age and genetic background cannot be changed, Type 2 Diabetes can often be prevented through weight loss and by maintaining a healthy weight if diagnosed and acted upon early.

CSIRO KicStart Type 2 Diabetes Study

A joint study by the CSIRO and the University of Adelaide**  was conducted to see what improvements could be achieved in obese diabetic subjects by inducing weight loss (with and without additional exercise). KicStart™ was used to replace 2 meals each day. The table below summarises some of the important results for well recognised cardiovascular disease risk factors that were achieved in the study :

Variable Starting (average) After 12 weeks (average)
Weight 101.6 kg 92.5 kg (overall mean weight loss of 8.8%)
BMI 34.2 kg/m2 31.2 kg/m2
Waist Circumference 112.6 cm 102.3 cm
Blood Pressure 133.8 / 75.7 mmHg 126.0 / 71.9 mmHg
Total cholesterol 4.52 mmol/L 4.03 mmol/L
HbA1c  7.89 %  6.45%

Of particular note, the reduction in HbA1c observed in this study (approximately 1.5%) has been associated with an approximate reduction of 31.5% in diabetes related deaths.

Scientific results

In addition to the results outlined above, this is the first known study to show a significant reduction in the scientific marker of oxidative stress known as MDA (malondialdehyde) following weight loss induced by calorie restriction in type 2 diabetes. As mentioned above, this is important because oxidative stress is believed to play a central role in the development of atherosclerosis and contribute to obesity related diseases such as hypertension as well as diabetes itself *. 


The table below summarises some of the important scientific results achieved in the study :

Variable

Starting (average) After 12 weeks (average)
Malondialdehyde (MDA) 0.81 micro mol/L 0.60 micro mol/L
24-hr urinary NO (nitrate/nitrite) 1.16 mmol 2.06 mmol
 HOMA
(Homeostatic model assessment – used in clinical research to assess insulin sensitivity)
 7.40  3.10
Insulin 15.69 mU/L 8.85 mU/L
HDL ('good') cholesterol 1.15 mmol/L 1.18 mmol/l
LDL ('bad') cholesterol  2.46 mmol/L  2.23 mmol/L

* Fenster CP, Weinsier RL, Darley-Usmar VM, Patel RP. Obesity, aerobic exercise, and vascular disease: the role of oxidant stress. Obes Res 2002; 10: 964–968.  


** Click here for the full details on the publication of this study.

More about KicStart VLCD

Introductory Video
About KicStart VLCD
Flavours
General Weight Loss
Heart Health
Sleep Apnoea
Reproductive Health
Common Questions

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